Abstract: The renewal and transformation of industrial heritage sites guided by culture has become fashionable， but lots of them are capital vassals of consumerism， gradually losing their inherent core of life and cultural diversity. Especially for such renewal projects in central urban areas， their position and value orientation of future development are crucial. Based on the system arrangement of cultural transformation studies and practices of industrial heritage sites， along with an analysis of cultural space development trends， this paper put forward the strategic conception of "universities would be the urban center in the era of knowledge economy" and a pan-university spatial model in order to reshape the cultural core that could support its sustainable development. Later， the construction mechanism of this model was extracted from several aspects of university concept， mode connotation， basic forms， architectural attributes and operation points， then showed a spatial logic oriented toward cultivating creative life and innovative culture as values， constructing new production relations around the uncertainty of innovation activities， combined with the practice of urban design. Finally， the university city prospect in future was preliminarily revealed in order to integrate and reconstruct the innovative space system of pan-university and return to the innovative essence of cities.