A novel prefabricated frame structure system was proposed, featuring "prefabricated beams and columns, prefabricated joints, and post-cast UHPC connections". A prefabricated frame and a cast-in-place frame were designed, and quasi-static tests were sequentially conducted to investigate their seismic performance. The test results showed that the overall seismic performance of the new prefabricated frame was equivalent to that of the cast-in-place one. Subsequently, a prefabricated frame model was established using finite element software. The numerical simulation results exhibited good agreement with the test results: the concrete damage patterns were similar, the yield load and maximum bearing capacity showed minor deviations, the energy dissipation capacity was comparable, and the hysteresis curves as well as the skeleton curves demonstrated high consistency. On this basis, the effects of beam longitudinal reinforcement ratio, column axial compression ratio, and concrete strength on the seismic performance of the novel prefabricated frame were investigated individually.The parametric analysis results showed that with the increase of longitudinal reinforcement rate of the beam, the bearing capacity increased significantly, while the energy dissipation capacity decreased。 The displacement ductility showed a trend of increasing first and then decreasing, the displacement ductility reached the maximum when the reinforcement ratio was 1.3%. The column axial compression ratio was varied within 0.75, with the increase of axial compression ratio, the bearing capacity of the prefabricated frame showed minimal change and remained at a high level, but its ductility and energy dissipation capacity decreased. With the increase of concrete strength, the bearing capacity of the prefabricated frame increased, while the structural ductility decreased. However, when the concrete grade exceeded C50, the bearing capacity of the prefabricated frame could not be improved further.
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