By using finite element to simulate the medhanical propersies of the prefabricated prestressed channel slab structure system under explosion load, the simulation results of scaled model were compared with the test results, through comparing the mechanical properties and failure mode, the model accoded with experiment was established, and based on the full scale model, the dynamic performance and deformation performance prefabricated prestressed channel slab structure in the civil air defense under explosion load were simulation and analyzed. The results showed that the dynamic constitutive model of high strain rate could well simulate the mechanical properties and failure mode of the structure under explosion load. Under the action of nuclear level 6, nuclear level 5, nuclear level 4B and nuclear level 4, the concrete damage under compression and tension was less than 0.5. The prefabricated prestressed channed plate hds good blast-resistant performance under explosion load, and the overall ductility ratio of the structure was more flon 7.5.