One industrial production workshop contains many heavy mezzanines,whose torsional vibration effect under bi-directional earthquake action is taken into account,hence the brace setting of the column which support the mezzanines and design of the wind-resistant column which is near to mezzanines are all different from common portal frame.Aiming at these difficulties,FEA software SAP 2000 is used for structural calculation and analysis,the efficient design methods are reached,good results are achieved after these methods are applied to this project.