Based on anti-seismic mechenism of the mega-frame structure,multi-rib open-web frame structure system with embedded concrete frame units is put forward.Though analyzing the horizontal earthquake action of multi-rib open-web frame structure by ETABS program,it is calculated and compared the variation rules of several major structural dynamic properties according to the density of frame grid element.The result shows that multi-rib open-web frame elements improve lateral stiffness of frame,and it can solve the torsion problem,which caused by short of lateral stiffness of ordinary frame or elements' arrangement.Pushover analysis shows multi-rib open-web frame structure obeys the ductility failure mechanism: first frame unit,then outer frame,and the safety margin of structure has been raised under strong earthquake.