The application of retard-bonded prestressed technique is introduced in the design of concrete grid-beam structure with the span of 32.4 m33.2 m with irregular boundary condition of Chengde City Museum.The design method of prestressed concrete grid-beam structure is introduced,and the secondary moment of prestressing is calculated according to the balanced loads of prestressing considered in the design.The nominal stresses and ultimate moments of the concrete girders are calculated considering the secondary moments.The design method can be referenced in the designing of retard-bonded prestressed concrete beams especially for that of the grid-beam structures.