Abstract: In view of the current problems existing in the steel structure building industry, such as low industrialization degree, low utilization rate of components and profiles, and low level of production automation, this paper took the steel frame structure system based on hollow tubular material columns as the object and conducted research from two aspects: the section specification sequence of hollow pipes and the standardized design of the structure. The requirements of civil buildings for steel component dimensions and structural cost-effectiveness were analyzed, and the bottlenecks and countermeasures for applying hollow tubular materials in civil buildings were clarified. Key technologies for the standardized design of steel frame systems, components, and connection nodes were developed to achieve effective integration of design and construction, thereby enhancing the overall project efficiency. The research outcomes were demonstrated in a parking building project. Comparative analysis with existing structural systems showed that the demonstration project achieved a 97.81% utilization rate of standardized components, a 78.5% node standardization level, a 208.3% increase in construction efficiency, and a 53.1% reduction in comprehensive energy consumption, demonstrating significant exemplary effectiveness.