Abstract: Industrial superstructures are a new type of industrial space model, which realizes the efficient use of urban industrial space and also brings new safety risk factors to industrial parks. In order to scientifically and accurately assess the safety risks of industrial buildings, the paper proposed a safety risk assessment index system for industrial buildings based on the theoretical framework of "risk source-risk exposure-mitigation force", which consists of three guideline layers of risk source control, carrier toughness, and mitigation force, as well as 20 secondary indicators. At the same time, combining the network analysis method (ANP) and the object-element topology model to determine the indicator weighting system and evaluation method, the establishment of industrial superstructure safety risk assessment model, the industrial superstructure safety risk assessment data to realize topology quantification, and then enhance the objectivity of the assessment results. The paper took an industrial superstructure park in Shenzhen as an example, and the analysis results showed that the safety risk level of the industrial superstructure park was light risk, and the assessment results were better, which was in line with the actual situation; through a comparison, it was found that the assessment method proposed in the paper was practical and scientific; the park should focus on the construction of the resilience level of the disaster-bearing body, strengthen a small amount of hazardous chemicals management, reasonably control the risks of productive vibration, etc., and strengthen the capacity of risk monitoring and early-warning, in order to better guarantee the safety of industrial superstructures.