Abstract: The purpose of the paper is to explore the design and transformation path of industrial heritage protection and renewal based on the "catalyst" theory, and to activate the spatial design strategy of industrial wasteland in old industrial cities. The paper analyzed the current situation of industrial heritage and established the enthusiasm and feasibility of catalyst theory in the design method of industrial heritage renewal. Taking Baotou Sugar Factory as an example, the value of "catalyst" elements was evaluated and screened out, the design of functional space and cultural elements was activated, and the activation of "catalyst style" industrial heritage space was explored. Based on the three-stage design strategy of catalyst preparation, catalyst element screening and activation, and catalyst reaction guidance, the paper adopted design strategies such as spatial organization, environmental system design, and event activities, the inventory space of industrial heritage was organically updated, enabling sustainable development of industrial culture and providing new ideas and research methods for the activation of industrial areas in old industrial cities.