Abstract: China has a large scale of new and existing buildings, but in recent years, building safety accidents have occurred frequently. Research studies have shown that building safety accidents are closely related to design. By improving or optimizing the design, the safety level of the full life cycle of the building can be effectively improved. At the same time, conducting safety control throughout the full life cycle of buildings during the design phase has low cost and high efficiency. Therefore, conducting safety design research is of great significance for safety control throughout the full life cycle of buildings. Based on the Shenzhen Bay Super Headquarters Tower C project, breaking the traditional design mode in the design phase was broken and a joint design team consisting of construction party, design, safety consulting, contractor, and property management was formed. In addition to considering the needs of occupational safety and health in the design, a safety design concept of full life cycle, general scenario, multi-hazards was innovatively proposed, and was applied to the design of the Shenzhen Bay Super Headquarters Tower C to effectively prevent and reduce the occurrence of safety accidents during the subsequent construction and operation phases of the Tower C project. Finally, corresponding strategies and suggestions were proposed for the difficulties encountered in the safety design process. Through this innovative practice, it provided a useful reference for the application and promotion of safety design concepts in high-rise building design in China.