Abstract: As China's urban construction gradually develops from incremental expansion to stock renewal, the renewal and reuse of existing industrial heritage areas has become an important topic of China's urban development. Taking the industrial heritage district of Zhengzhou No.2 Grinding Wheel Factory as the main research object, using the theory of space syntax, from the five aspects of integration degree, coordination, comprehensibility, connectivity value, and selectiveness, a quantification research on the space of Zhengzhou No.2 Grinding Wheel Factory at both macro and mioro scale was conducted combined with heat maps; simultaneously, the vitality degrees of the space before and after the renovation were compared. It was found that there were some problems such as remote geographical location, lack of internal commercial system and low accessibility of internal roads in the Industrial Cultural and Creative Park, and corresponding spatial renewal strategies were put forward, which could provide a reference for the space protection and redevelopment of Zhengzhou No.2 Granding Wheel Factory's industrial heritage areas and similar industrial heritage areas.