Abstract: The number of asymmetrical joints in complex long-span buildings is gradually increasing. The asymmetry is mainly reflected in different component sizes and different steel ratios. Compared with conventional symmetrical joints, there are many differences in the force transmission mechanism, failure mode and bearing properties of asymmetrical joints, so the design cannot be completely based on the calculation method of the existing conventional joints. Based on this, taking the asymmetric joints of a project in China as an example, ABAQUS software was used to conduct three-dimensional modeling. The seismic performance characteristics of asymmetric joints were analyzed through the hysteresis curve, skeleton curve, stress and damage distribution of joints, and the peak load at this time was taken as the seismic performance standard for subsequent optimization. Using the artifical bee colony algorithm, with the interface size and profile steel size as the input conditions, the seismic performance as the boundary condition, and the economy as the objective function, the secondary development of ABAQUS based on the Python language was carried out, and the optimal interface size and content were automatically calculated. The combination of steel ratio realized the optimal design of asymmetric joints. The research results could improve the level of refinement and intelligence in architectural design.