Abstract: In order to study the overall mechanical properties and failure forms of the prefabricated CFST column-RC beam frame with embedded steel, based on the actual engineering, a single-story two-span prefabricated frame structure was designed and fabricated for static load tests and numerical simulations, the test results showed that the structure exhibitsed typical three-stage failure characteristics, and the failure section appeared on the beams on both sides of the central column, which was a certain distance from the core area of the frame joint; it had a high safety reserve; the joints had good force transmission performance, each part of the components could be deformed in coordination, and the prefabricated frame had good integrity. After verifying the accuracy and reliability of the finite element model, the finite element method was used to carry out parametric expansion analysis, and the effects of beam concrete strength, beam width, longitudinal rebar strength, longitudinal rebar reinforcement ratio and steel-concrete joint section length on bearing capacity of the structure were studied respectively. The calculation results showed that:within the range of this parameter, increasing the beam concrete strength, beam width, longitudinal rebar strength, reinforcement ratio and length of the joint section could improve the bearing capacity of the structure; the improvement of the bearing capacity was obvious, but the increase became smaller when the value was larger; the embedded section steel could control the occurrence of critical cracks.