Abstract: Existing codes and standards adopt qualitative and quantitative methods to assess the safety of concrete frame structures, which can hardly judge the relative safety of structures at the same safety level. According to the stress characteristics of concrete frame structures, this paper built a hierarchical safety assessment model, combined the existing codes and standards in structural design, testing, and identification to construct a safety grade evaluation index system for component inspection items, and established comprehensive evaluation matrices for inspection items on the basis of membership function theory. Moreover, it developed a three-level fuzzy comprehensive evaluation method for the safety of concrete frame structures. The engineering cases with the safety of the main design structure rated as A, B, C, and D according to the current identification standards were designed, and the structural safety was evaluated by the proposed method in this paper, the maximum membership degree method, and the weighted rank average method for comparative analysis. The research results show that the structural safety evaluation model based on the analytic hierarchy process (AHP) can reflect the stress characteristics of concrete frame structures. Using the Delphi method to determine the fuzzy sets of the importance of the factors can give full play to the collective wisdom of experts in the evaluation and can better reflect the fairness of empowerment. The fuzzy comprehensive evaluation method based on the AHP model, fuzzy sets of factor importance, and comprehensive evaluation matrices of component inspection items can quantitatively evaluate the safety of concrete frame structures. Moreover, its results can achieve the highest degree of coincidence with the safety grade evaluation results of current specifications, and the average consistency rates of the component layer, sub-unit layer, and appraisal unit layer are 71.9%, 91.7%, and 100%, respectively.