Abstract: In order to study the seismic performance of a museum adopting a measure of seismic isolation and shock absorption, a 1/30 scale model of the structure with rubber isolation bearings beneathe column bottoms of ground floors and buckling-restrainted braces in the upper structure was conducted on a shaking table for earthquake simulation tests. Experimental research showed that subjected to various levels of earthquakes, the combined seismic isolation and shock absorption structure was only slightly damaged, the first of translation natural vibration frequency in the Y-direction was reduced by 9.1% subjected to the fortification earthquake, and the first torsional frequency reduced by 6.1% subjected to the rare earthquake. The acceleration amplification factor was 0.45 in the isolation storey, and the upper structure was also less than 1.0. The energy consumption performance of isolation bearings became better and better with the increase of earthquake intensities. From the energy consumption of only about 4 kN·mm under frequent earthquakes to the maximum energy consumption of about 426 kN·mm under rare earthquake, the combined measure for the structure achieved the expected shock absorption goal well.