Abstract: A super high-rise commercial and residential building was taken as an example, combined with the calculation results of frequent earthquake using YJK and MIDAS software, the overrun situations in terms of total height, the ratio of inter-story drift angle to torsional inter-story drift, local conversion of vertical structural members, and the adopted strengthening measures were analyzed. The analysis results showed that:less-wall frame structure system with partial column-wall conversion was suitable for this kind of building, the elastic inter-story drift angle limits could be interpolated according to the proportion of the overturning moment at the bottom. The results of floor comfort check for the long-span cantilevering area could meet the requirements of Technical Standard for Human Comfort of the Floor Vibration (JGJ/T 441-2019).The results of elastic time-history analysis should be taken into account to adjust the floor seismic force in the design of components, the elastic-plastic inter-story drift angle obtained by static pushover under severe earthquakes was less than 1/100, which could meet the performance design requirements.