Abstract: With the development of industry, industrial buildings are developing towards the direction of large span, large column spacing, large tonnage and ultra high-rise. However, the structural system of tall and heavy steel structure plants has not been systematically studied in domestic specifications, and its structural system has not yet formed a complete conclusion. Based on the design of a heavy-duty steel structure plant, the application of the roofing system composed of concrete-filled steel tubular lattice column and spatial pipe truss was studied. The selection idea from foundation to superstructure was described in detail, and the span of the enclosure structure was reduced by optimizing the form of spatial structure. The finite element software SAP 2000 was used for the overall analysis, and the calculation of key components and joints was studied. By consulting relevant information, the overall stability, strength, deformation, settlement and other indicators of the structure were determined, which were controlled from the overall structure to local components to ensure the accuracy and reliability of the analysis results. According to the complex geological conditions, the control standards of pipe piles were adjusted in time and applied to subsequent related projects, which had achieved good application effect and economic benefits.