Abstract: Under the background of focusing on urban regeneration and improving the quality of the stock spaces, how to better reuse railway heritage in China’s mega cities is a key to achieve the goal of high-quality development. Through the analysis of international and domestic cases of railway heritage conservation, the paper focused on interpreting the practice process of the section of Shanghai-Wusong Railway and Shanghai-Hangzhou Railway and surrounding areas from the obsolescence of important transportation arteries and functions to new transportation forms, which can drive activation so as to lead the urban composite regeneration functional corridor. Based on the summary of experience trends, the research proposed that railway heritage areas should play an important driving role in urban historic inheritance and comprehensive regeneration of mega cities. The study proposed the need to coordinate the railway heritage and surrounding areas with high correlation, form the new concept of railway heritage areas, comprehensively recognize and conserve the multi value system of society, economy, culture, history, and other aspects, expand and improve the object system, which including intrinsic elements, derivative elements, and intangible elements, establish characteristic functional guidance, implement policies in zones and sections, and the multiple renewal measures that can integrate the macro structure of city and drive the revitalization of surrounding communities were adopted, the supporting work mechanisms and specific policy supply for diversified integrated governance were established, so as to ultimately achieve the regeneration goal of driving high-quality urban development, providing high-quality life, and enhancing the comprehensive competitiveness of the city.