Abstract: The construction period of super high-rise building is long. In the whole construction process when the overall stiffness of the structure has not been formed, the safety of the structure under various construction loads, environmental wind and earthquake in the construction period was one of the key problems worthy of attention. In order to study the above problems, the numerical simulation method was adopted in this paper. The influence of strong earthquake on structural safety during construction was analyzed at different stages when the overall stiffness of the structure is incomplete. The South Tower of the Yinchuan Greenland Center super high-rise project was taken as an example. The structure consists of an outrigger truss connected steel frame-reinforced and concrete core tube. The birth and death technology of the element in ANSYS was used to simulate the whole process of the construction of the South Tower. Through calculation and analysis, the obtained maximum stress was compared with the allowable stress of the material, the maximum displacement was compared with the displacement limit required by the specification, and the safety of the structure was evaluated. The results showed that the maximum stress, inter-story displacement and inter-story drift ratio were smaller than the limits in the specification, and the structure could meet the reliability requirements during construction. It was found that the outrigger truss could significantly improve the lateral stiffness of the structure before and after connecting the inner and outer tubes, the maximum Y-direction displacement was reduced by 12.1%, and the maximum Mises stress of the outer frame tube and the core tube was reduced by 33.3% and 25.2% respectively.