Abstract: To resolve the contradiction between pedestrian and motor vehicle traffic in mixed urban residential and industrial land-use blocks, this study established a set of models for the quantitative analysis of spatial movement based on the principle of space syntax. These were applied to the optimal design of walkways in a mixed land sample area of the Changsha Tianxin Economic Development Zone. The investigation data showed that the traffic flow of motor vehicles in the sample area was significantly related to the spatial movement attribute of the road network; the local pedestrian flow was weakly related to the spatial moving attribute of the pedestrian network which presented a hollow state of peripheral street agglomeration and internal streets isolation. Two optimization schemes of walkways layout were put forward, and the current situation and the optimization schemes were compared and analyzed. The results showed that increasing the street crossing was beneficial to the pass-through ability for pedestrians, and increasing the density of the walkways network was beneficial to the accessibility for pedestrians. The spatial movement attribute analysis method could effectively evaluate the rationality of walkways structure and help to realize the urban demands for improving the living and business enviroment and production-city integration.