Abstract: Taking the structural response of frame structures under earthquake as a constraint, the seismic performance of frame structures with friction dampers was optimized by computer-aided integration technology. Using ABAQUS software, a finite element analysis of frame structures with or without friction dampers was carried out to obtain the displacement and acceleration responses of each layer of the structure. ISIGHT software was integrated with ABAQUS to optimize the mechanical parameters of friction dampers, to obtain the optimal damping design scheme under the condition of deploying the same number of dampers. The results showed that the parameter design method of friction dampers based on an optimization algorithm could effectively optimize the seismic design of the structure, and the application of the process could greatly improve the operability of the automatic optimization design of damper parameters in engineering applications. Univariate optimization and multivariate optimization methods were used respectively, and the optimization results showed that the displacement and acceleration responses of the top layer of the structure were significantly reduced compared with those before optimization.