Abstract: In the post-industrial era, cultural and creative industries are growing rapidly. With its unique landscape, many old industrial districts have transformed into ideal spaces for the development of cultural and creative industries. Taking the cultural and creative parks transformed from old factory in Guangzhou as an example, the paper studied the factors influencing the satisfaction of these parks, so as to provide suggestions for future improvement. Based on the traditional location theory, the paper introduced the scene theory to construct the index system of influencing factors of satisfaction of these parks, and used the factor analysis method to evaluate the influencing factors. The study found that the characteristics and location conditions of cultural activity scenes were the key factors influencing the satisfaction of the cultural and creative parks transformed from old factories. Other cultural scene characteristics, such as convenient services and facilities, talent and cultural values, also played important roles in the transformation. In order to achieve long-term and healthy development of the cultural and creative parks, the development trend of cultural and creative industry should be closely followed, the level of scene construction should be improved, personalized cultural and creative parks should be built, the construction of talent team should be strengthened, the supporting facilities of park should be optimizied, and finally, the corresponding planning and policy guidance should be improved.