Abstract: The hospital building reinforcement project in Jinnan District of Tianjin was taken as the engineering background in this study. Based on the performance-based seismic reduction control objectives, three reinforcement schemes of energy dissipation and seismic reduction were adopted, namely scheme 1 (buckling restrained brace), scheme 2 (viscous damper) and scheme 3 (buckling restrained brace + viscous damper). The damping effects of the three reinforcement schemes of energy dissipating and seismic reduction in high-rise structures were compared in according to the time-history analysis results of SAUSAGE software. The study showed that:under the action of frequently occurred earthquakes, using scheme 2 to strengthen the structure had the best damping effect; under the action of rarely occurred earthquakes, schemes 1 and 3 were better than scheme 2; using scheme 2 to reinforce the structure could achieve the damping target of performance 3, but could not meet the requirements of the building's uninterrupted operation under rarely occurred earthquake. The use of scheme 1 and scheme 3 to strengthen the structure could achieve the seismic reduction target of performance 2. As far as the control of the vertex displacement of the weak axis of the structure, the reinforcement effect of scheme 3 was better than scheme 1.