Abstract: Space superposition design strategy is a kind of spatial organization method that vertically superimposes the main tall and large space on one another. Taking the Mentougou Sports and Cultural Center as research object, the use of space superposition design strategy in the green building design of tall and large space in the cultural and sports center was studied, the analysis from the aspects of space intension, energy consumption reducing, simplified structure, material structure and operation optimization was conducted, and the contribution of space superposition design strategy to green building design was discussed. A series of design factors taking space superposition design strategy as the core, in association with the green properties of building, the strategy matrix for green building design was constructed, the green properties of tall and large space could be improved effectively, and higher aims of green building could be realized.