Abstract: The structure form of a project in shenzhen is "frame-support structure with suspension layer", which consists of core tube and six mega suspension frames arranged by asymmetric staggered layers. According to the installation sequence, the finite element software MIDAS was used to simulate the whole construction process and calculate the deformation. The deformation of tower construction was controlled by core tube reverse pre-deflection and outer frame structure pre-lifting. At the same time, according to the comparative analysis of construction simulation, the optimal support unloading sequence was selected to achieve the overall deformation control of the structure. It was found that the deformation value before and after unloading was basically in accordance with the theoretical calculation.