Abstract: Due to the different material characteristics of steel and concrete with time, there will be vertical deformation difference between the outer steel frame column and the inner concrete core tube in the construction process of hybrid structure combined with diagrid steel frame and concrete core tube, and excessive deformation difference will affect the construction quality and structural safety. Considering the time-varying effect of the construction process, the finite element analysis model was established by the method of variable stiffness stage by stage to simulate the whole construction process. The analysis results showed that with the construction process, the vertical deformation value and vertical deformation difference of the diagrid column, frame and concrete core tube increased, and the deformation growth rate was slow first, then fast and then slow. According to the numerical simulation results of the whole model and the deformation diagram of the diagrad column, the processing control compensation of the component was obtained. The leveling quantity of concrete core tube was proposed by piecewise accumulation leveling method.