Abstract: In view of the fluctuation of the quality of tuff manufactured sand in Taizhou area, Zhejiang,the influence of tuff manufactured sand on the performance of concrete was explored. The effects of different batches of manufactured tuff sand, manufactured limestone sand and river sand on mechanical properties and durability of concrete were studied. The results showed that the performance of the concrete with 20% mineral admixture was better than that of pure cement concrete. The grey correlation analysis was used to analyze the correlation between the content of stone powder, content of mud block, roughness and the 7 d compressive strength,28 d compressive strength, electric flux and cracking area of concrete. And two relational degree matrices were obtained. It was concluded that the content of manufactured stone powder was the main factor affecting chloride ion penetration resistance of concrete. While the main factor affecting the crack resistance of manufactured sand concrete was the content of mud. The correlation between compressive strength and roughness was the greatest, and when the content of stone powder was not more than a certain range, the influence of stone powder content on the compressive strength of concrete was very small. The permeability and crack resistance of concrete with manufactured tuff sand were more sensitive to the content of limestone powder and mud than that of concrete with manufactured limestone sand, and were more affected by the quality fluctuation of manufactured sand.