Abstract: Based on the combination of hydraulic synchronous sliding technique and construction prestressing technique applied in the long-span steel roof construction of Hongdao International Exhibition Center construction, the paper studied the combined application of the two techniques by taking the influence of construction prestressing on the construction process as the breakthrough point. The results showed that the removing temporary support sequence of the sliding unit and the time of filling the gear bar should consider the influence of construction prestress; the application of construction prestress changed the stress stiffness of the sliding unit and increased the risk of out-of-plane instability of the sliding unit, so it was necessary to determine whether to take reinforcement measures according to the specific project; the effects of sliding boots unsynchronization on the mechanical properties of the sliding unit during the sliding process were discussed with consideration of prestressing superposition effect.