Abstract: Concrete structures serving in cold regions are inevitably affected by freeze-thaw cycles. In this paper, the compressive constitutive relationship of self-compacting concrete after 0, 50, 100, 150, 200, 250 and 300 freeze-thaw cycles was investigated. The results showed that with the increasing freeze-thaw cycles, the mass loss of specimens increased, and the relative dynamic elastic modulus decreased. The self-compacting concrete could achieve the level of F300. The elastic modulus and peak stress of the specimen remained stable in the early stage of freeze-thaw test, and decreased significantly after 150 freeze-thaw cycles. As the number of freeze-thaw cycles increased, the peak strain decreased first and then increased, and the lateral deformation coefficient decreased. Based on the test results, the normalized compressive constitutive model of self-compacting concrete after freeze-thaw cycles was established, which was in good agreement with the experimental results.