Abstract: As a new kind of structure system，middle-high ecological hybrid composite wall structure is ecological， environmental，energy-saving，and has the advantage of energy dissipation and vibration reduction． Besides，it can be built rapidly． The system is mainly composed of prefabricated concrete vertical constraint components，hidden beam and assembly cast-in-place floor slab． The results indicated that under horizontal load，block，sash and frame could interact，and bear loads together． They played a role in turn in elastic stage，elastic-plastic stage and failure stage of the test． This made the middle-high ecological composite wall end up with multiple seismic linesblock-sash-vertical constraint component． On the basis of experimental study，the finite element software was used to analyze the influence factors of each line of defense，the effect of block strength for the first defense line，the size of the rib beam and frame column，the reinforcement of rib beam and rib column for the second defense line，the reinforcement of vertical constraint component for the third defense line． According to numerical analysis the influence rules of different factors were summarized which provided theory support for the later engineering practice． Studies showed that the matching between the relative strength and relative stiffness of different defense blocks，grid structures and three vertical restraint members was the effective guaranteed to realize three seismic lines． The seismic design method of the middlehigh ecological composite wall hybrid structure on the basis of three seismic lines could satisfy the personalized requirements of the performance goals design in structure．