Abstract: Prefabricated steel frame structure with inclined support joints is a new kind of steel structure，currently the studies of its construction simulation is few． In this paper，a 30-story prefabricated steel frame structure with inclined support joints was taken as engineering background． It was simulated to obtain the law of vertical deformation of the prefabricated steel frame structure with inclined support joints in construction simulation． At the same time，the influence of inclined support on vertical displacement of the 30-story prefabricated steel frame structure with inclined support joints in construction simulation was studied; getting the conclusion that inclined support had great impact on the vertical displacement of corner column and middle column，but had little impact on side column．