Abstract: Using orthogonal test method，based on energy method and taking the damping energy dissipation of sliding base-isolated structure as the response index，it was explored the effect under the Ⅱ，Ⅲ，and Ⅳ sites conditions of the associated parameters of sliding base-isolated structure on damping energy dissipation of structure and their sensitivities were analyzed． It was found that the damping energy dissipation of sliding base-isolated structure was more sensitive to the friction coefficient and the natural period of superstructure，and was insensitive to the mass ratio． The sensitivities of the damping energy dissipation of superstructure and isolation layer to the other parameters were more different，and the sensitivity sequence of parameters might be inconsistent．