Abstract: In order to study the strength，integral stability，local stability and rigidity etc of circular hole cellular beams，experimental investigations and finite element analysis of three simply supported circular hole cellular beams and three steel-concrete composite cellular beams were conducted． The influences on mechanical performance of circular hole cellular beams of different making method ( with or without weld on web) ，flange width，hole size，the width of beam pier and the combined effects were compared and analysed． And the stress distributions on the loading point and pedestal point of the beam were acquired． Experimental and finite element analytical results showed that the impact degree of weld on web on the capacity and rigidity of cellular beams was generally within 20%． And broadening flange，installing stiffener and increasing the width of beam pier could improve the bearing capacity of the cellular beams． The load carrying capacity and the initial stiffness of steel-concrete composite cellular beam were significantly improved as compared with non-composite cellular beams．