Abstract: Based on the finite element model and discrete model of soil surrounding pile, the space S-R model and finite element method was adopted to establish a simplified model and an integrative model which contains a single-layer cylindrical latticed shell, pile and its foundation soil. The soil was replaced with spring in the simplified model, and it was compared with the integrative model. The applicability and accuracy of the space S-R model for analyzing the large span space structure considering pile-soil-structure interaction (PSSI) are studied. The results show that the simplified model can simulate natural vibration characteristic and seismic response of the shell fairly well, and it is convenient to be used in engineering. The error of the first vibration frequency of the shell calculated by the simplified model is less than 10% compared with the results of the integrative model. The maximal error of the peak acceleration of node is 13.05% when it subjected to earthquake loads. The maximal error of the nodal displacement is 7.2%, and the maximal error of the internal force of the members was 9.59%.