Abstract: The in-patient building of a hospital is a structure with three layers of brick and concrete, built in 1976, class B building.There are cracks on the upper wall by the uneven subsidence due to foundation flooding, and the seismic design of the original structure was not fully realized, the seismic capacity is low.According to the status of the building the static pressing pile was used, concrete structural columns and beam were added to stabilize the foundation of structure, and strengthen the constraints of the upper structure, so as to raise its integrity and seismic ability obviously, and a good seismic reinforcement effect was got to guarantee the safe use of the structure within its follow-up life of 20 years.