Abstract: Imitating timber-framed reinforced concrete buildings constructed during the period of the Republic of China are typical architectural heritages with Chinese characteristics.Most of theses buildings bear some important historical and cultural information.They should be rationally strengthened according to the preservation rule of cultural relic.Based on strengthening project of a imitating timber-framed reinforced concrete building constructed during the period of the Republic of China in Zhejiang Province, some key problems in strengthening design of this kind of building were roundly discussed, including methods of testing and appraisement, computing and analyzing, concrete members reinforcement and brick wall reinforcement, etc.Some effective methods were introduced to solve the problems, such as the concrete columns and beams were strengthened with steel wire netting polymer mortar method, the concrete slabs were strengthened with steel meshed polymer mortar method, which could make a continuing service life of the building be more than 30 years.Which provided a reference for strengthening similar projects.