Abstract: The paper briefly introduces the characteristics of the structure with staggered stories,and taking a high-rise shear wall structure with staggered stories for example,according to the requirements of the relevant specification,an analysis was done using different structure analysis softwares,which was checked by the elastic time history analysis.According to above analysis results,it was put forward the matters needing attention in the design process of high-rise shear wall structure with staggered stories,and combined with standard,the corresponding a seismic measures were taken,and the optimization design was done under the premise of safety,which reduced project cost.It was expected to be a reference for future similar projects.