Abstract: The main building of Guangzhou Railway Station was built with complex structural system, its lower partstructure is railway bridge, and the middle part structure is large-span prestressed concrete frame structure, and theroof is large-span prestressed steel structure．To meet the schedule requirements, reversed constrution was applied．The steel roof structures were constructed first, and then the rail beams, drop-off platform and overhead floor．Thisprogram finally saved 45 to 60 d for installation of the steel structure, V beam structure and 21 meter floor．In order toinvestigate the impact on the roof prestressed steel structure of the reversed construction and prestressing of theconcrect, the integral model was built, and construction simulation was conducted, and the results were compared withthose of one time loading simulation．A reliable theoretical basis was provided a for making the prestressing programfor prestressed steel and prestressed concrete, which provided a reference for smooth construction of the project．