Abstract: The precise integration method and Wilson- method are combined to compute the structural dynamicequation, and wilson- precise integration method is proposed, and applied to structural seismic time-historyresponse analysis. The method through introducing Wilson- method basic assumptions, the structural dynamicdifferential equations of order reduction, then the application of precise integration method and Newton Cotes formulaof integration not only reduces the matrix of order and avoids the matrix inverse. Finally, some examples are given, the calculation results show that the method has good adaptability to seismic action, and good accuracy and highefficiency, which can be applied in the project.