Abstract: Based on wind tunnel test of Wuxi New District Science and Technology Communication Center, the windpressure distribution was analyzed under the condition of with and without surrounding buildings. Moreover, the shapecoefficients of three typical regions of the plum-blossom-shaped roof were studied. Several conclusions about aerointerference of surrounding high-rise buildings on large-span curved roof were provided. Although the mostdisadvantageous wind direction and wind pressure have changed while aero-interference occurred, the roof of theinterfered building still mainly bear negative wind pressure and the most fragile location is still along eaves. Windpressure of the interfered building is acutely increased under the action of wind-catching effect. Wind pressure of theinterfered building changes from negative to positive value under the action of wind-obstructing effect. The concave ofroof will bear the greatest sucking load when the direction of its trough is identical to wind direction because eddycurrents cooperate with wind-catching effect, which should be focused in the design of the curved roof.