Abstract: Facing the global environmental problems and the shortage of natural resources,the design methods of old buildings reuse need to be researched urgently.Design flaws often cause irreparable damage.howewve,the objectivity and scientificalness of design will be improved greatly if advanced science and technology as well as the relevant data provided by them can be used.Based on the reuse design of state key laboratories,this paper discusses the support of the computer simulation technology in architecture reuse design.