Abstract: Because of the eccentricity and irregularity of the frame-bent structure for an industrial workshop, based on the prototype of the principal workshop of a thermal power plant, the spatial computational model of integral structure was established, modal analysis and elastoplastic time history analysis under two-directional horizontal earthquake were made. Combined with the former pseudo-dynamic experiment and quasi-static experiment, the dynamic properties and the spatial deformation performance were studied on emphasis. The result shows that the stiffness of longitudinal direction and the transverse direction is abrupt, which makes the torsional effect evidently, and the weak parts are more, which need attention in its design.