Abstract: Based on practical project,a pseudo-static test was conducted on a 6-story RC frame model with special-shaped columns,which is 1/3 in size of the prototype under 8 degree seismic intensity. The anti-seismic property is appraised comprehensively by analyzing the hysteretic behavior,ductility,plastic hinges of beams and columns,strength and rigidity deterioration regression. The results show that RC frame with special-shaped columns has good anti-seismic property. Finite element analysis of the RC frame was conducted. The analytic result agreed well with the test result. Hence the FE model was reasonable,which could be used for the research on the RC frame structure with special-shaped columns.