Abstract: Utilizing structural analysis program ANSYS 8.1, and using shear span ratio of wall, cross-section shape and size of hidden-frame column as parameters,it is conducted the performance analysis of middle-high story multi-ribbed slab structure under the horizontal and vertical loads. The influence of global bending for internal force carried by hidden-frame column, and interacting properties between wall-slab and hidden-frame column, and features of the structural drift are discussed. Which provides a basis for rational defining cross-section shape and size of hidden-frame column, and a proposal for matters needing attention in the structure design is also put forward.