Abstract: Runyang Yangtse River Highway Bridge is the longest bridge at present,it is prac tically significant to health monitoring, diagnosis, forecast and evaluation of injury influenced by disasters, during its building and working, also, it is the purpose of the Health Monitoring System of Runyang Bridge. As one of the most i mportant problems of the system, optimum placement of sensor must be sloved rati onally. From this point of view, in detail this paper introduces the primary aca demic gist, which contains analytic result of finite element model and optimum p lacement of sensor in girder based on generalized genetic algorithm, and sensor placement for the Health Monitoring System of Runyang Bridge.