Abstract: Adopting the common and base isolation and non-islotion systems，comparative analysis of structure’s seismic performance was conducted on a multi-storey custom steel structure residence． El centro wave，Tianjin wave and an artificial earthquake wave are the seismic input． A two-degree of freedom Bouc-Wen hysteretic model was used to simplify the vibration isolation structure when analyzing the ductility demands． A brief analysis of the life cycle cost of this residence was also worked out． The results demonstrate that the gradually matured seismic isolated technology can be applied to steel structures as well． With the satisfaction of required bearing capacity，the seismic isolation layer has effectively controlled the vibration of superstructure，the structural response to earthquake has been effectively reduced and the interstorey acceleration response has also been greatly reduced，the safety of this structure has been guaranteed． Which meets the higher requirements towards the comforts of residence structures．