Abstract: The current anti-seism design method of civil engineering structure possibly loses system optimal solution because it does not consider the mutual coupling effect between structure design and control design． The collaborative optimization strategy is used for the integrated optimization of steel structure and control systems． The equation of motion for steel structure including MＲD under coupling earthquake is built，where the instantaneous optimal control strategy is applied for the control design． The integrated optimization model for the controlled structures is established． The multi-objective AFSA is chosen as the optimization method for the integrated optimization． The results of a numerical example show that structure and control system have better properties after the integrated optimization than those after the serial design，and the optimal structural weight under coupling earthquake is larger than that under horizontal earthquake only．