Abstract: Restricted by the thermal process layout，space layout of the main power house of a power plant is complex and with poor overall performance． A tradition ofRC main powerhouse structure with more weaknesses and low safety stock，its using in high seismic intensity regions is restricted． In this paper，SRC frame-shear wall hybrid structure system was put forward，and a 1 000 MW main powerhouse is taken as a research object，seismic performance test was carried out to study the structural deformation capacity，stiffness degradation rule，failure mode and energy dissipation capacity．Research results show that SRC frame-shear wall hybrid structure has godd seismic and economic erformance; Which can be better used in large-scale thermal power plant in high seismic intensity region．