Abstract: The development of industrial prefabricated steel structure especially conforms to the strategic requirement of dissolving excess production capacity，development of green building and ecological civilization construction in China． It is the only way to truly achieve industrialization and modernization for China's construction industry． It also ensures the quality and speed of post-disaster reconstruction and the urgent request of seismic safety． This paper analyzed the current bottleneck of industrialization of industrial prefabricated steel structure in China． The problems of industrial prefabricated steel structure system and innovation of the joint in the new structure system，standard specification establishment，global optimization of steel structure design of prefabricated steel structure system with diagonal bracing at joints，structural overall stability，the mainboard and column stability，severe earthquake elastoplastic analysis，experiment of single cross framework，performance experiment of flange bolt connection and beamcolumn connections， and the safeguard measures of stiffness of the assembled floor are studied．Research achievements have been applied to the pilot project successfully．